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. 2018 Dec 18;9:633. doi: 10.3389/fgene.2018.00633

FIGURE 10.

FIGURE 10

A schematic illustration depicting the role of Sox11 regulation in RGCs survival and axon regeneration. The differential response is observed in both overexpressing Sox11 or knocking-down Sox11. Upregulation of Sox11 promotes robust axon regeneration of some RGCs types but kills α-RGCs (Norsworthy et al., 2017). Downregulation of Sox11 aids RGCs survival (Welsbie et al., 2017) but negates the axon regeneration facilitated by Pten deletion.