. 2018 Dec 18;5:354. doi: 10.3389/fmed.2018.00354

Table 1.

Clinical trials using EPCs as therapeutic agent, registered under www.clinicaltrials.gov registry (22^nd Sept 2005–12^th Apr 2017).

NCT	Condition	Phase	n	Cell type	Cell surface marker(s)	Cell culture condition	Status	Sponsor(s)	Published results
NCT00936819	Acute Myocardial Infarction	II	100	PB-EPCs or eNOS-EPCs	CD31, CD34, CD14, CXCR4, VEGFR2	2-3 days culture in fibronectin coated plates	Recruiting	Ottawa Hospital Research Institute	NR
NCT01049867	Coronary Artery Disease	I/II	10	BM-EPCs	CD133⁺	NR	Unknown	Hospital y Clinica OCA, S.A. de C.V.	NR
NCT00384514	Coronary Artery Disease	II	24	PB-EPCs	NR	NR	Unknown	TheraVitae Ltd	NR
NCT00289822	Coronary Artery Disease	II	75	PB-EPCs	NR	0 or 3 days culture	Terminated	Johann Wolfgang Goethe University Hospital	De Rosa et al. (16)
NCT00629096	Dilated Cardiomyopathy	II	27	BM-MNCs	NR	NR	Completed	Fundación Pública Andaluza Progreso y Salud	NR
NCT00221182	Heart Disease	I/II	1	PB-EPCs	CD34⁺	NR	Terminated	Foundation for Biomedical Research and Innovation	NR
NCT00694642	Refractory Angina	I/II	28	EPCs	CD133⁺	N/A	Completed	Pilar Jimenez Quevedo	Jimenez-Quevedo et al. (17)
NCT02605707	Chronic Ischemic Stroke	I/II	30	EPCs	NR	NR	Unknown	Southern Medical University, China	NR
NCT01468064	Ischemic Stroke	I/II	20	BM-EPCs	NR	NR	Unknown	Southern Medical University, China	NR
NCT01595776	Critical Limb Ischemia	I/II	8	PB-EPCs	CD133⁺	NR	Completed	IRCCS Policlinico S. Mattteo	Arici et al. (18)
NCT02454231	Critical Limb Ischemia	II/III	45	PB-EPCs	CD14⁺, CD34⁺	NR	Completed	University of Florence	NR
NCT00523731	Critical Limb Ischemia	I	6	PB-EPCs	NR	Cells cultured in X-vivo 15 serum free medium supplemented with autologous human serum, VEGF and heparin for 5 days	Completed	TheraVitae Ltd	Mutirangura et al. (19)
NCT02287974	Critical Limb Ischemia	I/II	20	BM-EPCs	CD133⁺	NR	Active	Andalusian Initiative for Advanced Therapies - Fundación Pública Andaluza Progreso y Salud	NR
NCT02474381	Diabetic Foot	NR	60	EPCs	CD133⁺	NR	Unknown	Shanghai 10th People's Hospital	Zhang et al. (20)
NCT00221143	No Option Critical Limb Ischemia	I/II	15	PB-EPCs	CD34⁺	NR	Completed	Translational Research Informatics Centre, Kobe, Hyogo, Japan	Kawamoto et al. (21), Kinoshita et al. (22)
NCT02915796	Peripheral Arterial Disease	I	345	PB-EPCs	CD133⁺	Mononuclear cells isolated, re-suspended in RPMI-1640 and then injected into the ischemic area	Recruiting	Shanghai 10th People's Hospital	Huang et al. (23)
NCT00306085	Peripheral Atherosclerosis	I	20	BM-Cells	CD34⁺	Cells sorted by the MarrowXpress system and immediately transplanted	Unknown	University of Naples	Malone et al. (24), Cobellis et al. (25)
NCT00641836	Idiopathic PAH	NR	98	PB-EPCs	VE-Cad⁺, KDR⁺, CD34⁺, AC133⁺	Cultured on fibronectin coated flasks in Medium 199 for 5 days	Completed	Zhejiang University	NR
NCT00257413	Idiopathic PAH	NR	31	PB-EPCs	VE-Cad⁺, KDR⁺, CD34⁺, AC133⁺	Cultured on fibronectin coated flasks in Medium 199 for 5 days	Completed	Zhejiang University	Wang et al. (26)
NCT00372346	Idiopathic PAH	NR	40	PB-EPCs	vWF⁺, CD31⁺, CD34⁺	Cultured on fibronectin coated flasks in EGM-2 for 10-14 days	Unknown	Zhejiang University	NR
NCT00469027	PAH	I	7	PB-eNOS-EPCs	CD14⁺, CD31⁺	Isolated and cultured on fibronectin coated flasks for 7-12 days	Completed	Northern Therapeutics	Granton et al. (27)
NCT01333228	Liver Cirrhosis	I/II	14	BM-EPCs	CD31, CD34, CD14, VEGFR-2, VEGFR-1, CD133, CD90, CD117, vWF, CXCR1, CD45, ID1	BM-EPCs isolated via Ficoll gradient, cultured on fibronectin coated plates in endothelial complete medium for 4 days	Completed	Clinica Universidad de Navarra + Universidad de Navarra	D'Avola et al. (28)
NCT03109236	Liver Cirrhosis	III	66	BM-EPCs	CD133⁺	NR	Recruiting	National University Hospital, Singapore	NR
NCT01112189	Lymphedema	I/II	20	BM-EPCs	NR	NR	Completed	Hospital Universitario Dr. Jose E. Gonzalez	Maldonado et al. (29)
NCT01089387	Post Prostatectomy Erectile Dysfunction	I/II	18	BM-MNCs	NR	NR	Completed	Institut National de la Santé Et de la Recherche Médicale, France	NR
NCT03103295	Traumatic Bone Defects	I/II	20	PB-EPCs	NR	Cultured in EGM	Active	A.A. Partners, LLC	Vasyliev et al. (30)

BM, Bone Marrow; eNOS, Endothelial Nitric Oxide Synthase; EPCs, Endothelial Progenitor Cells; MNC, Mononuclear Cells; N/A, Not Applicable; NR, Not Reported; PAH, Pulmonary Arterial Hypertension; PB, Peripheral Blood.