FIGURE 1.

In vitro and in vivo models for developmental neurotoxicity screening. The possible neurotoxic effects induced by different chemicals can be addressed by using several in vitro and in vivo systems. In vitro cytotoxicity models are cheap and fast, but over-simplified and provide limited and preliminary neurotoxicity data. These findings are implemented performing neurotoxicity tests on in vivo animal models. Each in vivo system possesses different advantages and limitations. In this framework, zebrafish represent excellent comparative vertebrate systems.