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. 2018 Dec 18;9:1479. doi: 10.3389/fphar.2018.01479

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Copyright © 2018 Nie, Jiang, Zhang, Tian, Li, Lu, Yang and Shi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Dendrobium nobile Lindl. alkaloids (DNLA) improved clearance of autolysosomes in hippocampi of 13-month-old APP/PS1 mice. The APP/PS1 transgenic mice of 9 months old were fed with DNLA (40 and 80 mg/kg) and metformin (Met) (80 mg/kg). In contrast, APP/PS1 control group and WT control group were fed with isovolumic vehicle per day for 4 months. One month before the end of administration, Lateral ventricle was injected with AVV9_mRFP-GFP-LC3B. The brain section was observed under the fluorescence microscope.