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. 2018 Dec 18;9:2908. doi: 10.3389/fimmu.2018.02908

Figure 4.

Figure 4

Cytokine response of human macrophages exposed to HRV16 or TLR agonists for 24 h and then challenged with NTHi or LPS. Human macrophages were exposed to HRV16 (red bars), LPS (blue bars), CpG (orange bars) or MI (black bars) for 1 h and rested overnight. Then they were exposed to NTHi or LPS for 2 h and supernatants were collected and analyzed by MSD. MSD results for (A) IFNγ, (B) IL10, (C) IL12p70, (D) IL1β, (E) IL4, (F) IL6, (G) IL8, (H) TNFα. *p < 0.05 Kruskal Wallis Test with Dunn's Post Test vs. NTHi or MI + LPS. (I) Relative fold changes for cytokine production in HRV16, LPS or CpG exposed human macrophages. *p < 0.05, **p < 0.01 Two Way Anova with Dunnett's Post Test vs. NTHi or MI + LPS. Error bars represent standard error of the mean (SEM). n = 4 independent experiments on different donors.