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. 2018 Dec 18;9:2928. doi: 10.3389/fimmu.2018.02928

Figure 1.

Figure 1

Mice lacking IL-4Rα expressing B cells succumb to schistosomiasis by 10 weeks post-infection. IL-4Rα−/lox, mb1creIL-4Rα−/lox and μMT mice were infected with 100 S. mansoni cercariae and monitored weekly. (A) Survival kinetics of mice infected with S. mansoni (n = 8–10 mice). Survival curves were compared using Logrank test. *p < 0.05 and **p < 0.01 vs. IL-4Rα−/lox mice. (B) Granuloma area measured by microscopic analysis of formalin-fixed liver sections after H&E staining. (C) Liver fibrosis measured as hydroxyproline content normalized to tissue egg numbers (mean ± SEM, n = 4–6). (D) Cytokine production by total mesenteric lymph node cells restimulated with either SEA. (E) Cytokine production by total mesenteric lymph node cells restimulated with α-CD3 (mean ± SEM, n = 8–10 mice). Data are representative of two independent experiments. *p < 0.05, **p < 0.01 and ***p < 0.001 vs. IL-4Rα−/lox mice.