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. 2018 Dec 18;9:1472. doi: 10.3389/fphar.2018.01472

FIGURE 3.

FIGURE 3

QLY alleviated MTX induced side effects in rats. (A) Topological relationship between QLY and MTX in the RA-related biomolecular network modeling. (B) Possible mechanism underlying antagonistic effects of QLY against MTX induced toxicity revealed by network pharmacological analysis. (C) Effects of QLY on levels of intermediates in folate metabolism. (D,E) Levels of ALT and AST in serum. (F,G) Levels of HGB and RBC in the whole blood. Statistical significance: ∗∗∗p < 0.05 and ∗∗p < 0.01 compared with MTX group.