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. 2018 Dec 18;9:2996. doi: 10.3389/fimmu.2018.02996

Figure 4.

Figure 4

Effects of CLP challenge and linagliptin or IKK-16 post treatment on systemic inflammation in mice with T2DM. Mice from chow and HFD groups were randomized to undergo CLP or sham surgery. At 1 h after CLP, mice on HFD were randomized to receive linagliptin (10 mg/kg, i.v.), IKK-16 (1 mg/kg, i.v.), or vehicle (2% DMSO, 3 ml/kg). At 24 h after CLP, blood samples were collected and inflammatory cytokines concentrations were measured in the serum. (A) TNF-α, (B) IL-6, (C) KC, and (D) IL-10. Data was analyzed using one-way ANOVA followed by Bonferroni's post-hoc test and expressed as mean ± SEM. *P < 0.05 compared to HFD+CLP group. (n = 4 per sham surgery group and n = 6–8 per CLP group).