Table 1.
Baseline data for both chow and HFD groups before interventions (CLP or sham surgeries).
| Parameter | Chow | HFD |
|---|---|---|
| Net weight gain from baseline (grams) | 5.34 ± 0.47, n = 18 | 15.92 ± 1.19, n = 18* |
| Food intake$ (grams/mouse/week) | 3.38 ± 0.02, n = 12 (weeks) | 2.82 ± 0.03, n = 12 (weeks)* |
| Calorie intake$ (Kcal/mouse/week) | 17.29 ± 0.12, n = 12 (weeks) | 19.99 ± 0.24, n = 12 (weeks)* |
| AUC for OGTT (g.min/dl) | 29.65 ± 0.55, n = 18 | 47.73 ± 2.96, n = 18* |
| AUC for ITT (g.min/dl) | 6.57 ± 0.14, n = 5 | 9.63 ± 0.44, n = 10* |
| Fasting blood glucose (mg/dl) | 183.9 ± 4.68, n = 18 | 294.9 ± 13.9, n = 18* |
| Fasting plasma insulin (μIU/ml) | 20.16 ± 0.86, n = 10 | 71.80 ± 7.75, n = 9* |
| Ejection fraction (%) | 71.92 ± 0.81, n = 18 | 64.26 ± 0.95, n = 18* |
| Fractional shortening (%) | 40.73 ± 0.67, n = 18 | 34.73 ± 0.68, n = 18* |
| Fractional area change (%) | 51.37 ± 0.41, n = 18 | 45.8 ± 1.14, n = 18* |
| Left ventricle mass (mg) | 127.2 ± 2.92, n = 18 | 131.6 ± 4.04, n = 18 |
| Urea (mmol/L) | 9.47 ± 0.32, n = 18 | 9.45 ± 0.24, n = 18 |
| Creatinine (μmol/L) | 28.49 ± 1.71, n = 18 | 32 ± 1.25, n = 18 |
| Alanine aminotransferase (U/L) | 32.9 ± 4.05, n = 18 | 68.26 ± 9.54, n = 18* |
| Creatinine Clearance (ml/min) | 154.1 ± 17.56, n = 14 | 96.55 ± 8.79, n = 18* |
| Urine Albumin to Creatinine Ratio (μg/mg) | 0.19 ± 0.02, n = 10 | 0.72 ± 0.07, n = 10* |
| Triglyceride (mg/dl) | 183.6 ± 9.65, n = 18 | 175.4 ± 8.53, n = 18 |
| Total cholesterol (mg/dl) | 147.3 ± 2.24, n = 18 | 183.7 ± 3.56, n = 18* |
Mice fed a HFD were compared to age-matched mice fed a chow diet. Data is presented as mean ± SEM for n number of observations. Data was analyzed by unpaired t-test.
*
P < 0.05 vs. the chow-fed group. $: mean food intake of 18 mice in each group during the study period 12 weeks (n = 12). AUC, area under the curve; OGTT, oral glucose tolerance test; ITT, insulin tolerance test