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. 2018 Dec 18;12:934. doi: 10.3389/fnins.2018.00934

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Copyright © 2018 Dustrude, Caliman, Bernabe, Fitz, Grafe, Bhatnagar, Bonaventure, Johnson, Molosh and Shekhar.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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CeA depolarization to OX occurs via OXR1 but not OXR2. (A) Summary data for the application of OX A, or (B) OX B, in the absence or presence of receptor antagonists (OXR1 antagonist C 56 in red, and OXR2 antagonist JNJ10397049 in orange, n = 9–13 cells per condition). (C) Representative traces of OX A conditions and (D) OX B conditions. Solid bars under traces indicate perfusion of OX following 10 min perfusion of antagonist. (E) Schematics illustrating that OXR1 antagonism prevents OX mediated depolarization and OXR2 antagonism does not affect OX mediated depolarization. Data are means ± SEM, symbols indicate significance by Sidak’s post hoc test, p < 0.05, ^∗ between subjects, # within subjects.