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. 2018 Dec 18;12:934. doi: 10.3389/fnins.2018.00934

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Copyright © 2018 Dustrude, Caliman, Bernabe, Fitz, Grafe, Bhatnagar, Bonaventure, Johnson, Molosh and Shekhar.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Stimulated release of endogenous OX produces OXR1 dependent CeA neuron depolarization. (A) Representative PeF (20×) and CeA (40×) images demonstrate DREADD-mCitrine-positive cell bodies and fibers of cells expressing prepro-OX-DREADD-mCitrine virus. Boxed area is enlarged to show individual mCitrine-positive PeF neurons. (B) Schematic of regions that were imaged (-2.40 mm bregma for CeA, -2.80 mm bregma for PeF). (C) Summary data of Clozapine-N-oxide (CNO), DREADD agonist, effects for the indicated conditions (n = 9–13). (D) Representative traces from CNO treated neurons. CNO stimulated depolarization in animals expressing PeF-targeted DREADD virus except when OXR1 was antagonized by C 56. Solid bars under traces indicate perfusion of CNO. Data are means ± SEM, symbols indicate significance by Sidak’s post hoc test, p < 0.05, ^∗ between subjects, # within subjects.