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. 2018 Dec 18;12:934. doi: 10.3389/fnins.2018.00934

FIGURE 4.

FIGURE 4

CeA depolarization to OX occurs via sodium and calcium conductance mediated by PLC and NCX activity. (A) Representative traces of CeA neurons and (B) summary data for OX A treated cells with altered ionic gradients. Solid bars under traces indicate perfusion of OX. CeA depolarization did not occur when sodium or calcium conductance was reduced, but was maintained when potassium conductance was eliminated (n = 8–11 cells). (C) Summary data for OX and antagonist treated cells. PLC antagonist 10 μM U73122 and NCX antagonists 80 μM KB-R7943 and 3 mM NiCl prevented OX mediated CeA depolarization (n = 7–10 cells). (D) Schematic of putative signaling pathway by which OX mediates postsynaptic depolarization via PLC and NCX without contribution to depolarization by potassium channels. Data are means ± SEM, symbols indicate significance by Sidak’s post hoc test, p < 0.05, ∗ between subjects, # within subjects.