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. 2018 Dec 18;9:1817. doi: 10.3389/fphys.2018.01817

FIGURE 6.

FIGURE 6

Treatment with a TRPM8 antagonist (AMTB) suppresses the increased lung expression of p-ERK or p-JNK induced by M-CS or Non-M-CS in mice with subchronic exposure. p-ERK (A) and p-JNK (B) represent phosphor-extracellular signal-regulated kinase and phosphor-c-Jun N-terminal kinase, respectively. t-ERK and t-JNK represent total proteins of these two kinases. See Figure 2 caption for further explanations of the treatments in the five study groups of mice. The protein levels in the lung tissues were analyzed by Western blot. Data in each group are mean ± SEM from six mice. ∗p < 0.05 vs. the air-exposed group; @p < 0.05 vs. the Non-M-CS-exposed group; #p < 0.05 vs. the same type of CS group with vehicle treatment. Note that the increased expression of lung p-ERK or p-JNK induced by M-CS was higher than those induced by Non-M-CS, but the increased expressions induced by both types of CS were significantly reduced to similar levels by treatment with AMTB.