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. 2018 Dec 18;9:2963. doi: 10.3389/fimmu.2018.02963

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Copyright © 2018 Eger, Hiram-Bab, Liron, Sterer, Carmi, Kohavi and Gabet.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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BMDM in the presence of Ti particles, visualized using E-SEM. BMDM were cultured for 24 h in the presence of SLA-derived Ti particles. Each field was taken either in backscattered electrons (BSE) mode or secondary electrons (SE) mode. Dark patches represent macrophages; light-bright dots (A,C) are Ti particles. (B,D) Color representation of the Ti particles (red in BSE mode, green in SE mode). Note that most particles are outside the cells, as indicated by the similarity between the BSE and SE modes.