Figure 4.

Therapeutic administration of SCIgA/M limits St entry and reduces symptoms (A) Bacterial counts measured 6 days post-infection with 2 × 10⁷ St in Peyer's patches (PPs), mesenteric lymph nodes (MLNs), spleen, and liver from mice orally administered SCIgA/M 1 h after oral infection. (B) Weight loss and disease scores (see Materials and Methods) determined at day 6 post-infection of mice treated therapeutically with SCIgA/M as in (A). (C,D) Same experiments as in (A,B) with infection performed with 2 × 10⁶ St, followed by subsequent therapeutic oral administration of SCIgA/M 1 or 8 h after oral infection. Each panel compiles the results of 3 independent experiments, conducted with 3 mice per group. ns, non-significant; *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001.