Table 3.
Genetic, demographic and biochemical factors that affect bilirubin levels.
| Explanatory variables | Total bilirubin(TB) | Indirect bilirubin(IB) | Direct bilirubin (DB) | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Coefficient | R2 | P-value | Coefficient | R2 | P-value | Coefficient | R2 | P-value | |
| UGT1A1*28 | 3.743 ± 0.577 | 5.6% | 3.5%10−10 | 2.469 ± 0.383 | 4.8% | 4.5%10−10 | 1.269 ± 0.212 | 4.2% | 6.3%10−9 |
| UGT1A1*6 | 2.908 ± 0.476 | 7.1% | 2.9%10−9 | 1.869 ± 0.316 | 6.6% | 8.8%10−9 | 1.032 ± 0.175 | 6.0% | 9.7%10−9 |
| Sex(Male) | 1.599 ± 0.959 | 0.6% | 0.096 | 1.320 ± 0.637 | 1.1% | 0.039 | 0.277 ± 0353 | 0.1% | 0.433 |
| Age (years) | 0.136 ± 0.032 | 2.9% | 2.2%10−5 | 0.115 ± 0.021 | 10.0% | 8.7%10−8 | 0.021 ± 0.012 | 0.6% | 0.072 |
| WBC (%109/L) | −0.388 ± 0.215 | 3.1% | 0.072 | −0.183 ± 0.143 | 0.3% | 0.201 | −0.204 ± 0.079 | 5.8% | 0.010 |
| HB (g/L) | 0.150 ± 0.033 | 9.4% | 8.0%10−6 | 0.101 ± 0.022 | 6.3% | 6.0%10−6 | 0.049 ± 0.012 | 8.9% | 5.7%10−5 |
| PLT (%109/L) | −0.018 ± 0.006 | 1.8% | 0.002 | −0.010 ± 0.004 | 1.9% | 0.008 | −0.008 ± 0.002 | 2.8% | 3.7%10−5 |
| ALB (g/L) | 0.512 ± 0.127 | 1.6% | 6.8%10−5 | 0.306 ± 0.088 | 2.6% | 3.2%10−4 | 0.206 ± 0.047 | 3.7% | 1.4%10−5 |
| TBA (umol/L) | −0.391 ± 0.115 | 4.8% | 0.001 | −0.282 ± 0.077 | 4.2% | 2.7 × 10−4 | −0.108 ± 0.042 | 1.8% | 0.011 |
| BMI (kg/m2) | −0.144 ± 0.089 | 0.7% | 0.104 | −0.069 ± 0.059 | 0.3% | 0.245 | −0.076 ± 0.033 | 1.0% | 0.021 |