Table 4.
Distribution and multivariate analysis of UGT1A1 genotypes for participants with and without NAFLD.
| Explanatory variables | NAFLD | Non-NAFLD | P-value | OR (95%CI) | P-value | OR (95% CI)adjusted | P-valueadjusted |
|---|---|---|---|---|---|---|---|
| (n = 76) | (n = 327) | ||||||
| TB (μmol/L) | 16.2 ± 8.6 | 15.6 ± 7.5 | 0.548 | 1.009 (0.979–1.041) | 0.547 | 1.028 (0.971–1.088) | 0.349 |
| DB (μmol/L) | 5.9 ± 4.7 | 5.7 ± 2.4 | 0.622 | 1.025(0.949–1.107) | 0.526 | 1.028 (0.861–1.227) | 0.763 |
| IB (μmol/L) | 10.2 ± 4.9 | 9.9 ± 5.5 | 0.523 | 1.011(0.968–1.057) | 0.622 | 1.045 (0.962–1.234) | 0.300 |
| VARIANT UGT1A1*6 | |||||||
| G/G | 38 (50.0%) | 211 (64.5%) | 1.000 | ||||
| G/A or A/A | 38 (50.0%) | 116 (35.5%) | 0.019 | 1.819 (1.099–3.009) | 0.020 | 1.638 (0.780–3.442) | 0.193 |
| VARIANT UGT1A1*28 | |||||||
| 6/6 | 55 (72.4%) | 233 (71.3%) | 1.000 | ||||
| 6/7 or 7/7 | 21 (27.6%) | 94 (28.7%) | 0.846 | 0.946 (0.542–1.652) | 0.846 | 1.395 (0.614–3.170) | 0.427 |
| COMPOUND VARIANT GENOTYPES | |||||||
| 6/6; G/G or G/A; 6/6 or 6/7; G/G | 70 (92.1%) | 305 (93.3%) | 1.000 | ||||
| G/A or A/A and 6/7 or 7/7 | 6 (7.9%) | 22 (6.7%) | 0.719 | 1.118 (0.465–3.040) | 0.719 | 2.131 (0.589–7.704) | 0.249 |
Systolic blood pressure, diastolic blood pressure, fasting plasma glucose, total cholesterol, triglyceride, low-density lipoprotein, high-density lipoprotein, and uric acid were also included in the regression model and were not significant (each P > 0.05). Adjusted for age, sex, ALT, WBC, and BMI.