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Adenine (de)methylation dynamics. Adenine (A) is methylated at N6 of the purine ring by DNA N6-adenine methyltransferases 1 (DAMT-1), the writer, to generate N6-methyladenine (6-mA). SeqA protein, the reader, preferentially binds to hemimethylated (6-mA) DNA. 6-mA may get demethylated by the action of N6-methyl adenine demethylase-1 (NMAD-1) or DNA methyladenine demethylase (DMAD), the eraser.
