Table 1.
Participant characteristics
| 23vPPV in Pregnancy | |||
|---|---|---|---|
| Maternal characteristics at randomisation | Yes (n = 75) | No (n = 150) | |
| median(range) | |||
| Maternal age, years | 23 (17–39) | 24 (17–38) | |
| Household occupancy, people | 4 (1–12) | 4 (2–15) | |
| Household occupancy (< 5 years)a, people | 1 (0–4) | 1 (0–8) | |
| n(%) | |||
| Primigravida | 29 (39) | 50 (33) | |
| Completed year 10b | 61 (82) | 125 (84) | |
| Remote community residence | 23 (31) | 47 (31) | |
| Smoker | 36 (48) | 68 (45) | |
| Influenza vaccine in pregnancy | 9 (12) | 30 (20) | |
| Infant characteristics | |||
| median(range) | |||
| Gestational age at birth, weeks | 39 (35–41) | 39 (34–42) | |
| Birthweight, grams | 3293 (2060–4425) | 3338 (2080–4620) | |
| n(%) | |||
| Male | 36 (48) | 84 (56) | |
| Low birth weight (< 2500 g) | 7 (9) | 8 (5) | |
| Premature birth (< 37 weeks) | 7 (9) | 6 (4) | |
| Special or intensive care admission | 14 (19) | 31 (21) | |
| Breast fedc | 1 month study visit | 61 (92) | 106 (82) |
| 2 month study visit | 55 (90) | 97 (77) | |
| 7 month study visit | 43 (64) | 85 (63) | |
| Mother smokingd | 1 month study visit | 35 (53) | 63 (49) |
| 2 month study visit | 34 (57) | 68 (54) | |
| 7 month study visit | 46 (69) | 76 (56) | |
| 3 doses of PCV < 12 months | 64 (85) | 127 (85) | |
| 7vPCV | 38 (51) | 78 (52) | |
| 10vPHiD-CV | 15 (20) | 34 (23) | |
| Mixed schedule (7v/10v) | 11 (15) | 15 (10) | |
| median(range) | |||
| Age in days at PCV1 | 64 (41–240) | 63 (51–128) | |
| Age in days at PCV2 | 130 (103–311) | 132 (107–253) | |
| Age in days at PCV3 | 197 (150–349) | 197 (168–333) | |
PneuMum study vaccinations, sample collection and clinical examinations occurred over 5 visits: pregnancy (30–36 weeks), birth (< 72 h) and infant age 1, 2 and 7 months. Complete data were not available for some characteristics. For pregnancy vaccinated, and non-pregnancy vaccinated groups respectively the denominators for ahousehold occupancy (< 5 years) were: 75 and 149; for bcompleted year 10 were: 74 and 149; for cbreast feeding (non-exclusive) were: 66 and 129 at 1 month; 61 and 126 at 2 months; and 67 and 134 at 7 months and for dmaternal smoking were: 66 and 129 at 1 month; 60 and 127 at 2 months; and 67 and 135 at 7 months. PCV: pneumococcal conjugate vaccine; includes both the 7vPCV and 10vPHiD-CV. Where PCV dose dates were missing or outside the 12 month (−14 days) window the dose was coded as not received