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Effects of the E161K mutation in SCN5A, either in H558 or R558 background, on the fast sodium current (INa) of the Fabbri-Severi model of a human SA nodal pacemaker cell during simulated voltage clamp experiments. (A) Control (“wild-type”) and mutant INa during voltage clamp steps from a holding potential of -120 mV to test potentials of -40, -20, and 0 mV. (B) Current–voltage relationship of peak INa, as derived from these simulated voltage clamp experiments.
