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Bradycardic effects of the E161K mutation in SCN5A, either in H558 or R558 background, on the Fabbri-Severi model of a human SA nodal pacemaker cell at different levels of ACh (0–25 nM). (A) Cycle length. (B) Associated beating rate. (C) Percent decrease in beating rate relative to wild-type. Solid gray bars show the effect of a 50% reduction in fully-activated conductance of INa (gNa). Note the breaks in the vertical axes of (A,B).
