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. 2018 Dec 18;9:1795. doi: 10.3389/fphys.2018.01795

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Copyright © 2018 Wilders.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of the E161K mutation in SCN5A, either in H558 or R558 background, on the action potential and fast sodium current (I_Na) of the Maleckar et al. model of a human atrial myocyte. (A) Action potentials elicited at 1 Hz and (B) associated fast sodium current (I_Na) in the absence of ACh. (C) Action potentials elicited at 1 Hz and (D) associated I_Na during simulated administration of 10 nM ACh. Insets show membrane potential (V_m) and I_Na on an expanded time scale. Solid gray lines show the effect of a 50% reduction in fully-activated conductance of I_Na (g_Na).