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. 2018 Dec 18;8:632. doi: 10.3389/fonc.2018.00632

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Copyright © 2018 Xia, Zhou, Guo, Fu, Zhu, Li, Xu, Zheng, Zhang, Shan and Gao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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MALT1 protease activity endowed ABC-DLBCL cells with latent mitochondrial bioenergetics ability. Mitochondrial respiration profiles in ABC-DLBCL cells (A) and GCB-DLBCL cells (C) treated with vehicle or VRPR. (B) Baseline OCR and mitochondrial spare respiratory capacity (SRC) of the graphs in (A) were calculated. (D) Baseline OCR and SRC of the graphs in (C) were calculated. (E) Mitochondrial respiration profiles in GCB-DLBCL cells (BJAB and SUDHL-4 cells) that were either left untreated or stimulated for 12 h with PMA/Iono (P/I); zVRPR-fmk was added 12 h before stimulation where indicated. (F) Baseline OCR and SRC of the graphs in (E) were calculated. All the graphs represent as the mean ± SD of three independent experiments. *p < 0.05; **p < 0.01.