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. 2018 Dec 18;9:2896. doi: 10.3389/fimmu.2018.02896

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Copyright © 2018 Kuo, Teoh, Tuong, Leggatt, Mattarollo and Frazer.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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K14.E7xRb^ΔL/ΔL skin grafts are not rejected from immunocompetent syngeneic recipients. (A) Grafts of donor ear skin, as shown, onto C57BL/6 recipients at 21 and 42-days post grafting. (B) Area remaining of graft at the indicated time points (DPG). (C) C57BL/6 and E7TCR269 recipients were immunized with GF001 (50 μg) and QuilA (5μg) subcutaneously 7 days before grafting. (D) Representative photos of graft-bearing recipients on day 21 and day 63. K14.E7 skin (left) and K14.E7xRb^ΔL/ΔL skin (right). (E) Area remaining of graft at the indicated time points, compared to the graft on day 21. DPG, day post grafting. Analyses were done using one-way ANOVA, with Bonferroni's multiple comparison tests. Error bars showing mean ± SEM with n≥3. Result significance was shown, where ^**p < 0.01, ^***p < 0.001, and ^****p < 0.0001.