Figure 1.

Overview of RMGs and specifically mutated RMGs in human cancer. (a) The number of RMGs in cancers. In this figure, the outermost circle means each cancer type, and the numbers outside the circle are numbers of RMGs. The middle circle represents the organ to which each cancer belong. The inner circle indicates corresponding biological system, where RS, CS, IS, and LS mean the respiratory system, circulatory system, integumentary system, and locomotor system, respectively; (b) Protein classes encoded by all RMGs. Seven cancer types with specific protein classes enriched were shown; (c) The mutation rate distribution of RMGs in cancers. Each point corresponds to one single RMG, colored in term of mutation ratios; (d) specifically mutated RMGs. The numbers in brackets mean the number of smRMGs in each cancer type. Only top five RMGs were listed for cancers with more than five smRMGs. See also Supporting Information Table S2