Table 1.

Clinical details of patients carrying PRKN SVs

Patient (gender)	Age at onset	Age	PRKNMutations	Start location	First symptom	Tremor	Progression	Parkinsonism	Rigidity	Postural instability	Dystonia	Bradykinesia	Hypokinesia	Autonomic dysfunction	Pyramidal signs	Stride and sleep apnea	REM sleep behavior disorder	Falling	Response to levodopa	Other symptoms
FA_P1 (Male)	13	62	Delx5/Delx5	Limbs	Resting tremor	Rest, intention, limbs	Slow	Sy	Y	La	Y	Y	Y	Y	N	N	N	Y	Y	Eye lid apraxia or blepharospasm, incontinence, sensory polyneuropathy, impaired smell
FA_P2 (Male)	13	54		Limbs	Resting tremor	Intention, limbs, chin	Slow	Sy	N	La	N	Y	Y	N	N	N	N	Y	Y	Incontinence, sensory polyneuropathy
FA_P3 (Male)	13	50		Whole body	Whole body tremor	Rest, intention, limbs	Slow	Sy	Y	La	N	Y	Y	N	N	N	N	N	Y	Sensory polyneuropathy
FB_P1 (Female)	10	24	Delx2/Delx3	Limbs	Rigidity	Rest	Slow	Asy	Y	Y	Y	Y	N	N	N	N	N	Y	Y	None
FC_P1 (Female)	17	27	Delx4–6/Delx4	Whole body	Resting tremor	Rest	Fast	Sy	Y	Y	Y	Y	N	N	N	N	N	Y	N	None

Family A was previously reported in Taghavi et al., 2018 (Family 3).

As: asymmetric; Ea: early; FA_P1: family A, patient 1; La: late; N: No; Sy: symmetric; Y: yes.