FIGURE 1.

Altered FCs and their correlations with sustained attention deficits in patients with SCZ and with obsessive-compulsive disorder (OCD). (A) Two-sample t-test revealed that SCZ patients had reduced FC between left mPFC and bilateral ACC as compared with HCs. (B) SCZ patients had reduced FC between right mPFC and bilateral amygdala as compared with HCs. (C) Results of two-sample t-test showed that when the right mPFC as seed, OCD patients had reduced FC in left SFG and in bilateral thalamus as compared with HCs. (D) Scatter plots demonstrated that the reduced functional connectivity between left mPFC and bilateral ACC in SCZ group was negatively correlated with their enhanced intra-individual RT variations during SART. (E) Scatter plots showed that reduced functional connectivity between right mPFC and left SFG in OCD group was negatively correlated with their sustained attention deficits. For all image analyses, age, gender and education were controlled as covariates. Significance threshold was set at p < 0.05, FDR cluster level corrected, starting from voxel level p < 0.005 uncorrected. FC, functional connectivity; SCZ, schizophrenia; OCD, obsessive-compulsive disorder; HC: healthy control; SART, sustained attention to response task; IIV, intra-individual variation; mPFC, medical prefrontal cortex; ACC, anterior cingulum cortex; SFG, superior frontal gyrus.