Table 2.
Brain regions showing functional connectivity differences based on default mode network seeds among SCZ and OCD in comparison with HC.
Brain regions | Direction | Voxel | Peak coordinates (x/y/z; MNI) | Peak T values | Cohen’s d | ||
---|---|---|---|---|---|---|---|
SCZ vs. HC | |||||||
PCC as seed | None | ||||||
Left mPFC as seed | |||||||
Bilateral anterior cingulum cortex (BA32, 24) | SCZ < HC | 205 | 12 | 24 | 33 | 3.75 | 1.12 |
Right mPFC as seed | |||||||
Bilateral amygdala extending to striatum (BA48, 34) | SCZ < HC | 351 | −3 | −12 | −3 | 4.55 | 1.36 |
OCD vs. HC | |||||||
PCC as seed | None | ||||||
Left mPFC as seed | None | ||||||
Right mPFC as seed | |||||||
Left superior frontal gyrus (BA9) | OCD < HC | 163 | −12 | 54 | 45 | 4.90 | 1.47 |
Bilateral thalamus | OCD < HC | 163 | 9 | −15 | 6 | 4.24 | 1.27 |
SCZ, schizophrenia; OCD, obsessive-compulsive disorder; HC: healthy control; mPFC, medical prefrontal cortex; PCC, posterior cingulate cortex; BA, Broadmann area; x, y, z, coordinates of peak locations in the Montreal Neurological Institute space (MNI). Significance threshold was set at p < 0.05, FDR cluster level corrected, starting from voxel level p < 0.005 uncorrected.