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. 2018 Dec 19;9:3150. doi: 10.3389/fmicb.2018.03150

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Copyright © 2018 Han, Yang, Zhong and Ning.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Dominant and discrepant virus analysis and biomarkers analysis for control, pHTN, and HTN groups. (A) Relative abundance of the top 29 most dominant and discrepant viruses among control, pHTN and, HTN groups. The threshold of p-value of Kruskal–Wallis test is set to be 0.05 between every two groups. AVG, average relative abundance; C, control; P, pHTN; H, HTN. The relative abundance profile was transformed to Z score based on the average relative abundance of corresponding viruses. (B) Biomarkers analysis based on viral profile for control, pHTN, and HTN groups. A total of 334 high-quality annotations of viruses were selected for biomarkers analysis by LEfSe, and 32 viruses were identified as biomarkers. The pink labeled viruses were presented in both (A,B).