Table 3.

Greengenes taxonomic classification and relative abundance of key OTUs defining the GM differences between ASD and HCs.

Phylum	Family	Genus	Number of OTUs	ASD	HCs
Actinobacteria	Actinomycetaceae	Actinomyces	1	0.002 ± 0.001	0.039 ± 0.02
	Corynebacteriaceae	Corynebacterium	1	0.001 ± 0.001	0.021 ± 0.007
	Bifidobacteriaceae	Bifidobacterium (longum)	1	6.904 ± 2.021	15.302 ± 2.943
	Coriobacteriaceae	–	1	0	0.026 ± 0.016
	Coriobacteriaceae	Eggerthella (lenta)	1	0.081 ± 0.031	0.408 ± 0.113
Bacteroidetes	Porphyromonadaceae	Parabacteroides (distasonis)	1	0.043 ± 0.028	0
	Bacteroidaceae	Bacteroides	22	1.606 ± 1.121	0.003 ± 0.002
Firmicutes	Aerococcaceae	–	1	0.006 ± 0.002	0.059 ± 0.027
	Streptococcaceae	Streptococcus	5	0.065 ± 0.03	0.704 ± 0.176
	U. Clostridiales	–	3	0.09 ± 0.05	0.1 ± 0.07
		–	2	0.16 ± 0.15	0
		Ruminococcus	3	0.42 ± 0.19	0.04 ± 0.02
	Lachnospiraceae	Blautia	10	1.06 ± 0.38	2.99 ± 0.55
		Coprococcus	4	0.06 ± 0.02	0.3 ± 0.08
		Lachnospira	1	0.04 ± 0.03	0
		Roseburia	1	0.06 ± 0.05	0
	Peptostreptococcaceae	–	1	0.02 ± 0.02	0
		–	18	0.97 ± 0.36	0.1 ± 0.02
	Ruminococcaceae	Faecalibacterium (prausnitzii)	6	0.51 ± 0.31	0.04 ± 0.01
		Oscillospira	3	1.21 ± 0.5	0.15 ± 0.05
Proteobacteria	Enterobacteriaceae	–	4	0.407 ± 0.368	0.002 ± 0.002
	Pasteurellaceae	–	1	0.057 ± 0.049	0

Discriminant OTUs were identified using LEfSe algorithm and Metastats comparison (p < 0.05 for Metastats comparison and LDA > 2 with alpha < 0.05 for LEfSe). Mean ± SEM of key OTUs with relative abundance > 0.01% is reported. A more detailed table with average and SEM for each discriminatory OTU is provided as Supplementary Table S1.