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. 2018 Dec 19;9:1832. doi: 10.3389/fphys.2018.01832

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Copyright © 2018 Balaban, Halliday, Mendonca Costa, Bai, Porter, Rinaldi, Plank, Rueckert, Prasad and Bishop.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Computational model creation from an LGE-CMR image. (A) LGE-CMR image. (B) Image segmentation into enhanced and non-enhanced myocardium. (C) LV myocardial pixel intensity histogram and example intensity to fibrosis probability mapping. (D) Computational model with LGE intensities registered to image. (E) Zoomed in view of simulated fibrosis micro-structure. (F) Four conduction slowing zones in LGE. (G) Rule-based circumferential fibers.