Table 1.
Characteristics of the included genome-wide DNA methylation studies.
| References | Corhort source | Ethnicity | Subjects | Body mass Index(kg/m2)a |
|---|---|---|---|---|
| Dick et al., 2014 | Cardiogenics consortium | European | 459 | 25.9(3.6) |
| MARTHA | European | 339 | 24.2(4.4) | |
| KORA | European | 1,789 | 28.1(4.8) | |
| Pan et al., 2015 | GUSTO cohort | Asian | 991 | 1.3(0.1)b |
| Aslibekyan et al., 2015 | GOLDN | EA | 991 | 28(6) |
| ARIC | AA | 2,105 | 30(6) | |
| Al Muftah et al., 2016 | Qatari cohort | Caucasian | 123 | 28.3(6.2) |
| Twins UK cohort | Caucasian | 810 | 27.8(5.2) | |
| Main et al., 2016 | EUGENE2 Consortium | Caucasian | 137 | 27.9(6.0) |
| Wahl et al., 2017 | LOLIPOP | Asian | 2,680 | 27.6(4.4) |
| EGCUT Asthma | European | 173 | 22.8(3.0) | |
| EGCUT CTG | European | 96 | 26.7(5.1) | |
| ALSPAC | European | 701 | 26.6(5.3) | |
| Twins UK | European | 338 | 26.7(5.0) | |
| RS-III | European | 731 | 27.6(4.6) | |
| Life Lines Deep | European | 752 | 25.4(4.2) | |
| Leiden Longevity | European | 642 | 25.5(3.5) | |
| RS-BIOS | European | 762 | 27.8(4.2) | |
| LOLIPOP | Asian | 656 | 27.0(4.4) | |
| Mendelson et al., 2017 | FHS | European | 2,377 | 28.3(5.4) |
| LBC 1936 | European | 920 | 27.8(4.4) | |
| LBC 1921 | European | 446 | 26.2(4.0) | |
| Koh et al., 2017 | KoCAS | Asian | 692 | 19.4(1.3) |
| Wang et al., 2018 | EpiGO | AA | 128 | 18.8(1.3) |
| LACHY | AA | 284 | 24.1(5.6) | |
| BP stress cohort | AA | 228 | 31.4(8.6) | |
| Dhana et al., 2018 | RS | European | 1,450 | 27.7(4.4) |
| Xu et al., 2018 | Community volunteers | Mixed | 510 | 24.5(2.9) |
Values are shown as mean ± SD.
BMI was derived as weight (g) divided by height2 (cm2).
MARTHA, MARseille THrombosis Association; KORA, Cooperative Health Research; ARIC, Atherosclerosis Risk in Communities; GUSTO, Growing Up in Singapore toward Healthy Outcomes; FHS, Framingham Heart Study; EUGENE2, European Network on Functional Genomics of Type 2 Diabetes; ALSPAC, Avon Longitudinal Study of Parents and Children; RS-III, Rotterdam Study III; BIOS, Biobank-based Integrative Omics Studies; LOLIPOP, The London Life Sciences Prospective Population; LBC, Lothian Birth Cohort; KoCAS, Korean Child-Adolescent Cohort Study; EpiGO, Epigenetic Basis of Obesity-Induced Cardiovascular Disease and Type 2 Diabetes; LACHY: Lifestyle, Adiposity and Cardiovascular Health in Youth; BP, Blood pressure; RS, Rotterdam Study; AA, African American; EA, European American.