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. 2018 Dec 19;9:3106. doi: 10.3389/fmicb.2018.03106

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Copyright © 2018 de Moraes, Barateiro, Sousa and Penha-Gonçalves.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Proposed mechanism for BK sequestration by IE impacting on B2R expression and IE engulfment by trophoblast; (A) BK sequestration by IE, via interaction of BK with B2R on the IE membrane, impact on B2R gene expression in trophoblasts leading to decrease in mRNA transcription in these cells; increase of B2R⁺ trophoblasts in infected conditions compared to non-infected reflects less internalization of the complex BK-B2R due to lower BK availability. (B) B2R activation induces trophoblast invasion and migration phenotypes (Erices et al., 2011) and we hypothesize that this effect is mediated by IL-6; secretion of IL-6 downstream of B2R signaling is decreased in the presence of IE which may impact on trophoblast movement and IE phagocytosis by trophoblasts.