FIGURE 4.

Worse arthritis and psoriasis in LACC1 KO mice in the mannan-induced model of inflammation. LACC1 KO (red) and age-matched WT control (black) mice were administered 20 mg of mannan i.p. on day 0, 4, and 8. (A) Arthritis scores were assessed over time. (B) Number of arthritic paws at day 10. (C) Number of affected paws per animal (top panel), individual paw arthritis score (middle panel, number of paws in each group are in parentheses), or average psoriasis score (bottom) over time (left) or at day 10 post–initial injection of mannan (right). Data shown in (A)–(C) represent combined results of three independent experiments (n = 22–24 animals per group), including two cohorts of animals receiving 400 μg of anti-ragweed IgG control as shown in Fig. 6A. Time course data presented as mean ± SEM, and day 10 timepoint as mean ± SD. *p < 0.05, **p < 0.01.