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. 2018 Sep 18;7(1):251–253.e1. doi: 10.1016/j.jcmgh.2018.09.007

Figure 1.

Figure 1

Histologic staining of the stomachs of Lrig1-Kras or Mist1-Kras mice. (A) Sections from Lrig1 or Lrig1-Kras mouse stomachs at 2 month after tamoxifen injection or from Mist1 or Mist1-Kras mouse stomachs at 1 month after tamoxifen injection were examined by H&E staining. Dotted boxes indicate enlarged regions. Yellow arrows indicate eosinophilic SPEM cells, which contain clear cytoplasm filled with mucous. White arrows indicate chief cells, which contain darkly stained basophilic cytoplasm. (B) Sections of the stomach corpus from Lrig1-Kras or Mist1-Kras mice were stained for pERK1/2 immunostaining. Dotted boxes indicate enlarged regions. Black arrows indicate pERK1/2-positive SPEM cells at the base of metaplastic glands.