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Schematic diagram showing telomere structure, telomere-associated proteins (TRF1, TRF2, POT1, TIN2, TPP1, and RAP1; forming the shelterin complex), and telomerase in a mammalian oocyte. The 3' overhang of telomere end enters the doubled-stranded DNA to create a displacement (D-loop) and a telomere (T-loop) loop. The shortened telomeres are elongated by the telomerase enzyme, composed of a TERT and a TERC subunits, as well as by other components.
