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. 2018 Oct 8;64(6):469–476. doi: 10.1262/jrd.2018-110

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This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License. (CC-BY-NC-ND 4.0: https://creativecommons.org/licenses/by-nc-nd/4.0/)

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Fig. 3. — Estrogen-dependent prepubertal suppression of pulsatile LH secretion in female rats. Plasma LH profiles in cholesterol- (left panel) or E2-implanted (right panel) OVX rats at 26 (prepubertal period) and 41 (postpubertal period) days of age. Note that E2 implanted into the medial preoptic area (mPOA), ARC or subcutaneous (sc) space, but not into the paraventricular nucleus (PVN) or ventromedial nucleus (VMH), suppressed LH pulses in OVX rats in the prepubertal period. Arrowheads indicate LH pulses identified with the PULSAR computer program [70]. Originally published in Uenoyama et al. (2015) [69].