Table 1. Restoration of fertility by spermatogonial transplantation.
| Recipient type | Host treatment | Cell type (mouse origin) |
Concentration of transplanted cells |
Testis weight (mg) 1 | Number of fertile recipients (%) | EGFP+ offspring 2 (%) |
|---|---|---|---|---|---|---|
| W | No treatment | PS48-B6 (ROSA) | 108/ml | 14.1 ± 1.0 (2) | 0/2 (0) | 0 (0) |
| W | No treatment | PS48-B6 (ROSA) | 5 × 107/ml | 14.6 ± 0.6 (2) | 0/2 (0) | 0 (0) |
| W | No treatment | PS48-B6 (EGFP) | 3 × 107/ml | 26.4 ± 2.7 (3) | 0/5 (0) | 0 (0) |
| BDF1 | Leuprolide | MHY-B6 (EGFP) | 108/ml | 37.7 ± 40.8 (1) | 0/2 (0) | 0 (0) |
| B6 | Leuprolide | MHY-B6 (EGFP) | 108/ml | 24.0 ± 0.7 (2) | 0/6 (0) | 0 (0) |
| B6 | Acyline | MHY-B6 (EGFP) | 108/ml | 42.7 ± 4.9 (2) | 3/4 (75) | 2 (50%) |
Values are mean ± SEM. Recipient mice were kept for 194 to 634 days after transplantation. 1 In parenthesis, the number of animals that survived the whole experimental period is shown. 2 Recipients that sired EGFP+ offspring.