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. 2018 Dec 19;12:983. doi: 10.3389/fnins.2018.00983

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Copyright © 2018 Zheng, Bi, Yang, Zhao, Wang, Li and Zhou.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Glucose tolerance and insulin tolerance tests. (A,B) GTT and ITT in CRS and control mice. Both CRS-hyperglycemic and CRS-normoglycemic mice showed insulin resistance, but the latter had normal glucose tolerance. (C,D) Comparison of glucose tolerance and insulin tolerance in DEX and solvent (SV) injected mice 3 days after DEX withdrawal. At this time, DEX injected mice showed insulin-resistant hyperglycemia. (E,F) 7 days after the withdrawal of DEX, the efficiency of glucose uptake in DEX injected mice was increased and no longer showed fasting hyperglycemia and insulin resistance. Data were shown as means ± SEM, ^∗p < 0.01.