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. 2018 Dec 26;13:10. doi: 10.1186/s13008-018-0043-3

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© The Author(s) 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — TAp73 knockdown protects cancer cells from PpIX-induced cell death. a TAp73 knockdown with siRNA in H1299 cells as confirmed by qPCR. mRNA levels of TAp73 are not affected by 2.5 μg/ml PpIX. b TAp73 knockdown protects from PpIX-induced growth inhibition in H1299 cells. c, d Ablation of TAp73 protects from induction of proapoptotic target Noxa by PpIX on mRNA (c) and protein levels (d)