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. 2018 Aug 20;219(2):275–283. doi: 10.1093/infdis/jiy505

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Figure 2. — Morphology of normal anogenital skin specimens (A) and anogenital wart (AGW) specimens (B–D) stained by hematoxylin eosin (40× original magnification). The epidermal layers (stratum corneum [SC], stratum granulosum [SG], stratum spinosum [SS], stratum basalis [SB]), dermis, and dermal papillae [DP]) are labeled. AGW specimens can demonstrate abnormal thickening of the SS (acanthosis; B), thickening of the SC (hyperkeratosis; C), and/or thickening of the SG (hypergranulosis; C). AGW specimens also characteristically show parakeratosis (nuclei in the SC) and perinuclear cytoplasmic necrosis (koilocytes; D).