Table 1.
Human Immunodeficiency Virus (HIV) Target Cells, Granulocytes, and CD8+ T Cells in the Epidermis of Anogenital Wart Specimens Versus Donor/Site-Matched Control Tissue Specimens (CS) From HIV-Infected and Uninfected Subjects
| Variable | Control Specimens | Wart Specimens | Pa | |||
|---|---|---|---|---|---|---|
| HIV Negative | HIV Positive | HIV Negative | HIV Positive | HIV Negative vs HIV Positive | Wart vs Control | |
| Anal wart vs control specimens | ||||||
| CD1a+ cells | ||||||
| Mean ± SEb | 1.2 ± 0.2 | 1.1 ± 0.1 | 1.9 ± 0.3 | 2.6 ± 0.2 | NS | <.0001 |
| Matched pairs (n) | 10 | 10 | 10 | 10 | ||
| CD4+ cells | ||||||
| Mean ± SEb | 0.2 ± 0.1 | 0.3 ± 0.1 | 0.8 ± 0.1 | 0.6 ± 0.2 | NS | .0006 |
| Matched pairs (n) | 14 | 9 | 14 | 9 | ||
| CD68+ cells | ||||||
| Mean ± SEb | 0.04 ± 0.04 | 0.2 ± 0.1 | 0.7 ± 0.1 | 0.6 ± 0.1 | NS | <.0001 |
| Matched pairs (n) | 12 | 12 | 12 | 12 | ||
| CD8+ cells | ||||||
| Mean ± SEb | 0.9 ± 0.1 | 0.7 ± 0.1 | 1.6 ± 0.2 | 0.6 ± 0.1 | .002 | NS |
| Matched pairs (n) | 17 | 12 | 17 | 12 | ||
| CD15+ cells | ||||||
| Mean ± SEb | 0.03 ± 0.03 | 0.0 ± 0.0 | 0.6 ± 0.2 | 0.4 ± 0.1 | NS | .0002 |
| Matched pairs (n) | 16 | 16 | 16 | 16 | ||
| Genital wart vs control specimens | ||||||
| CD1a+ cells | ||||||
| Mean ± SEb | 1.1 ± 0.1 | 0.9 ± 0.2 | 2.9 ± 0.4 | 2.7 ± 0.5 | NS | .0006 |
| Matched pairs (n) | 7 | 5 | 7 | 5 | ||
| CD4+ cells | ||||||
| Mean ± SEb | 0.1 ± 0.1 | 0.3 ± 0.1 | 0.8 ± 0.3 | 0.8 ± 0.3 | NS | .026 |
| Matched pairs (n) | 7 | 6 | 7 | 6 | ||
| CD68+ cells | ||||||
| Mean ± SEb | 0.0 ± 0.0 | 0.0 ± 0.0 | 1.2 ± 0.4 | 0.8 ± 0.3 | NS | .015 |
| Matched pairs (n) | 3 | 4 | 3 | 4 | ||
| CD8+ cells | ||||||
| Mean ± SEb | 0.9 ± 0.2 | 0.5 ± 0.2 | 1.7 ± 0.2 | 1.4 ± 0.2 | NS | .002 |
| Matched pairs (n) | 9 | 4 | 9 | 4 | ||
| CD15+ cells | ||||||
| Mean ± SEb | 0.0 ± 0.0 | 0.0 ± 0.0 | 0.0 ± 0.0 | 0.0 ± 0.0 | NS | NS |
| Matched pairs (n) | 4 | 4 | 4 | 4 | ||
Abbreviations: NS, not significant; SE, standard error.
aBy two-way analysis of variance (main effects).
bData are semiquantitative cell density values.