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. 2018 Oct 4;219(2):323–334. doi: 10.1093/infdis/jiy506

Figure 5.

Figure 5.

MyD88 is required for monophosphoryl lipid A (MPL) + trehalose-6,6’-dicorynomycolate (TDCM) + squalene oil (MTS)–induced increases in immunoglobulin M (IgM) and immunoglobulin G (IgG) responses to serotype 3 pneumococcal polysaccharide (PPS3) and nitrophenyl (NP)–Ficoll. A, Wild-type (WT) and MyD88–/– mice were immunized with Pneumovax (~1 μg each PPS) alone or mixed with MTS intramuscular (IM) (n = 3–5 mice/group). Mice were boosted on day 30. *Significant differences between WT groups (P < .05). B, WT and Trif–/– mice were immunized with Pneumovax (~1 μg each PPS) alone or mixed with MTS IM (n = 5–6 mice/group). Mice were boosted on day 30. *Significant differences between WT groups. #Significant differences between Trif–/– groups (P < .05). C and D, WT and MyD88–/– (C) or Trif–/– (D) mice were immunized with 1 μg NP-Ficoll alone or mixed with MTS IM. Mice were boosted on day 30. *Significant differences between WT groups (P < .05) or between Trif–/– groups (P < .05).