Table 1.
Degradation kinetic equation and half-life of DOX in each experimental treatment.
| Item | Treatment | The initial concentration of doxycycline (mg/kg) |
P-value 1 |
|||||
|---|---|---|---|---|---|---|---|---|
| 4.4 | 8.0 | 10.9 | 13.2 | L | Q | C | ||
| First-order kinetic equation | A | C = 4.41e–0.057t | C = 7.95e–0.049t | C = 10.88e–0.047t | C = 13.20e–0.046t | – | – | – |
| B | C = 4.41e–0.021t | C = 7.95e–0.022t | C = 10.88e–0.026t | C = 13.20e–0.027t | ||||
| Half-life (d) | A | 12.21 ± 0.93Ba | 14.44 ± 0.68Bb | 15.42 ± 1.43Bc | 15.43 ± 0.85Bc | <0.001 | <0.001 | <0.001 |
| B | 33.63 ± 0.73Aa | 30.69 ± 0.46Ab | 26.78 ± 0.45Ac | 25.91 ± 2.16Ac | <0.001X | <0.001X | <0.001X | |
| R2 | A | 0.98 ± 0.009 | 0.98 ± 0.006 | 0.93 ± 0.250 | 0.95 ± 0.164 | <0.001 | <0.001 | <0.001 |
| B | 0.96 ± 0.169 | 0.94 ± 0.208 | 0.97 ± 0.002 | 0.97 ± 0.033 | <0.001X | <0.001X | <0.001X | |
a,b Within a column, means without a common superscript differ (P < 0.05). xP-value for interaction of treatment effect with initial concentration of DOX.