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. 2018 Dec 21;14:149–159. doi: 10.2147/IJN.S188003

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(A) Distribution of the PB aptamer relative to bone marrow vascular endothelium (red: Cy5-PB aptamer; blue: nuclei). (B) Colocalization of PB aptamer with a vascular endothelial cell marker in bone marrow (red: Cy5-PB aptamer; green: CD31; blue: nuclei). (C) Colocalization of PB aptamer with a vascular endothelial cell marker within tumor in bone marrow (red: Cy5-PB aptamer; green: CD31; blue: nuclei). (D) Higher binding affinity of PB aptamer to bone marrow endothelial cell compared with control aptamer ex vivo (^*P<0.05).