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. 2018 Dec 21;14:135–148. doi: 10.2147/IJN.S181296

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© 2019 Sun et al. This work is published and licensed by Dove Medical Press Limited

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Hemolysis and toxicity evaluation of three formulations.

Notes: (A) Photograph of hemolysis of red blood cells treated with Tween-CTX, NPs-CTX, and FA-NPs-CTX. (B) Optical image of hemolytic study of Tween-CTX, NPs-CTX, and FA-NPs-CTX. (C) LD50 evaluation of Tween-CTX. (D) LD50 values of Tween-CTX, NPs-CTX, and FA-NPs-CTX.

Abbreviations: CTX, cabazitaxel; FA, folic acid; FA-NPs-CTX, FR-targeted nanoparticles loaded with cabazitaxel; FR, folate receptor; LD50, median lethal dose; NPs-CTX, cabazitaxel-loaded nanoparticles; Tween-CTX, CTX dissolved in a mixture of Tween 80 and 13% ethanol (w/w) at a ratio of 1:4 (v/v).