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. 2018 Dec 21;14:135–148. doi: 10.2147/IJN.S181296

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© 2019 Sun et al. This work is published and licensed by Dove Medical Press Limited

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In vivo antitumor evaluation of different formulations against HeLa xenografts in nude mice after the intravenous injection of NS (control), Tween-CTX, NPs-CTX, and FA-NPs-CTX.

Notes: (A) Change of tumor volume. (B) Change of body weight. (C) Image of tumors obtained from nude mice at Day 20. (D) Tumor weight at Day 20 after excision from mice. Data are presented as the mean ± SD (n=5). **P<0.01, ***P<0.001 vs control; ^#P<0.05 vs NPs-CTX.

Abbreviations: CTX, cabazitaxel; FA, folic acid; FA-NPs-CTX, FR-targeted nanoparticles loaded with cabazitaxel; FR, folate receptor; NS, normal saline; NPs-CTX, cabazitaxel-loaded nanoparticles; Tween-CTX, CTX dissolved in a mixture of Tween 80 and 13% ethanol (w/w) at a ratio of 1:4 (v/v).