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. 2018 Dec 21;13:1–12. doi: 10.2147/BTT.S114530

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© 2019 Keyel and Reynolds. This work is published and licensed by Dove Medical Press Limited

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Synthesis and metabolism of GD2.

Notes: GD2 is synthesized via nine steps from ceramides (obtained likely preferentially via the de novo synthetic pathway). Ceramide is glycosylated, and then via additional steps GD2 is synthesized. GD2 can be metabolized to GD1b by GM1a/GD1b synthase.