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. 2018 Dec 21;13:153–160. doi: 10.2147/DDDT.S163197

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© 2019 Wang et al. This work is published and licensed by Dove Medical Press Limited

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(A) Dexmedetomidine reduces isoflurane-induced decrease of NMDAR 2B. (B) NMDAR 2B protein expression level in each group at 2 h, 12 h, 24 h, 3 day, 7 day and 28 day after isoflurane anesthesia. Quantification of NMDAR 2B is normalized to GAPDH.

Notes: **P<0.01, compared with control group; ^#P<0.05, ^##P<0.01, compared with isoflurane group (n=6). One-way ANOVA followed by Tukey’s post hoc multiple comparison tests was used for data analysis.

Abbreviations: Iso, isoflurane; Dex1, isoflurane with a single dose of dexmedetomidine; Dex2, isoflurane with dual doses of dexmedetomidine; h, hours; d, day.