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. 2018 Dec 21;14:161–180. doi: 10.2147/IJN.S187886

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© 2019 Lugert et al. This work is published and licensed by Dove Medical Press Limited

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Effects of SPION^LA-HSA-Ptx and Ptx on three-dimensional cell clusters.

Notes: (A, B) BT-474, (C, D) MCF-7, (E, F) MDA-MB-231, and (G, H) T-47D spheroids were treated with 36 nM free Ptx or particle-bound Ptx (SPION^LA-HSA-Ptx). In addition, a SPION^LA-HSA carrier control, a SPION- and Ptx-free negative control, and positive toxicity control containing 2% DMSO were utilized. The first column displays the projected two-dimensional area during the treatment. The second column shows representative pictures of the spheroids during the first 144 hours after treatment.

Abbreviations: DMSO, dimethyl sulfoxide; Ptx, paclitaxel; SPION, superparamagnetic iron oxide nanoparticles; SPION^LA-HSA, lauric acid- and human serum albumin-coated SPIONs; SPION^LA-HSA-Ptx, SPION^LA-HSA functionalized with Ptx.

Effects of SPION^LA-HSA-Ptx and Ptx on three-dimensional cell clusters.

Notes: (A, B) BT-474, (C, D) MCF-7, (E, F) MDA-MB-231, and (G, H) T-47D spheroids were treated with 36 nM free Ptx or particle-bound Ptx (SPION^LA-HSA-Ptx). In addition, a SPION^LA-HSA carrier control, a SPION- and Ptx-free negative control, and positive toxicity control containing 2% DMSO were utilized. The first column displays the projected two-dimensional area during the treatment. The second column shows representative pictures of the spheroids during the first 144 hours after treatment.

Abbreviations: DMSO, dimethyl sulfoxide; Ptx, paclitaxel; SPION, superparamagnetic iron oxide nanoparticles; SPION^LA-HSA, lauric acid- and human serum albumin-coated SPIONs; SPION^LA-HSA-Ptx, SPION^LA-HSA functionalized with Ptx.